Introduction
What is Pyrroloquinoline Quinone (PQQ)
Pyrroloquinoline quinone (PQQ) is a novel cofactor involved in cellular energy production and antioxidant activity. Discovered in the 1970s, PQQ has gained attention for its potential health benefits, particularly in enhancing mitochondrial function and protecting cells from oxidative stress.
Importance and Relevance
PQQ is crucial in the biochemistry of plants, animals, and humans, where it plays roles in cellular energy production and as a potent antioxidant. Recent research suggests that PQQ can influence various health aspects, including brain function, cardiovascular health, and overall energy levels, making it a subject of interest for both scientists and health enthusiasts.One of the main reasons why PQQ is gaining traction is due to its impressive redox potential. Redox reactions encompass all chemical reactions in which atoms have their oxidation state changed. In simpler terms, PQQ helps facilitate vital biological functions such as energy production and cell growth. It acts as a catalyst, speeding up these processes, contributing to overall health and wellbeing.
Boosting Mitochondrial Energy
PQQ’s role in energy production is particularly significant. It has been found to promote the creation of new mitochondria in our cells, the ‘powerhouses’ responsible for energy production. This implies that supplementing with PQQ could enhance energy levels, improve endurance, and contribute to overall vitality.
Neuroprotection and Cognitive Health
Beyond its role in energy production, PQQ has been linked to cognitive health, showing potential as a neuroprotective compound. Research suggests that PQQ can protect neurons from oxidative damage, one of the key factors in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease.
Liver Health
Supplementation with PQQ has been found to improve liver morphology and decrease the expression of inflammatory and fibrosis-promoting factors in animal models, suggesting a role in liver health.
Regulation of Enzyme Activity
PQQ regulates the activity of enzymes like lactate dehydrogenase, which is involved in energy production in various organs and tissues
Memory Function
When combined with CoQ10, PQQ has been shown to improve memory function, suggesting a synergistic effect that could benefit cognitive health
A Potent Antioxidant
PQQ is also an extremely potent antioxidant. It’s believed to be capable of carrying out 20,000 catalytic conversions compared to only 4 for Vitamin C, making it a significant player in the fight against oxidative stress and inflammation.
How does PQQ affect cognitive function in older adults:
Pyrroloquinoline quinone (PQQ) has been shown to improve cognitive function in older adults, particularly in terms of memory and attention. Key findings include:
- Memory Improvement: PQQ supplementation has been found to enhance complex and verbal memory in older adults, with improvements observed after 12 weeks of supplementation.
- Cognitive Flexibility and Executive Speed: PQQ has been shown to improve cognitive flexibility and executive speed in younger adults, with significant improvements observed after 8 and 12 weeks of supplementation.
- Processing Speed: Processing speed, which is the ability to quickly process information, has been found to be improved in younger adults after 8 weeks of PQQ supplementation, but not in older adults.
- Antioxidant Properties: PQQ’s antioxidant properties are believed to contribute to its cognitive benefits, particularly in older adults where oxidative stress and inflammation are more prevalent.
- Neuroprotective Effects: PQQ’s neuroprotective effects, which include reducing oxidative stress and inflammation, are thought to help preserve cognitive function and potentially prevent age-related cognitive decline.
Basically ,PQQ has been found to have a positive impact on cognitive function in both younger and older adults, although the specific benefits may vary depending on age group and cognitive parameters.
What dosage of PQQ is recommended for cognitive benefits:
Based on the search results, the recommended dosage of pyrroloquinoline quinone (PQQ) for cognitive benefits is:
- Most supplements contain 10-40 mg of PQQ per serving, with 20-40 mg being the typical dosage range.
- In the human study cited, participants took 21 mg of PQQ disodium salt per day and experienced improvements in various cognitive domains like memory, attention, and executive function.
- The search results indicate that starting with 20 mg of PQQ per day is generally considered a safe and effective dose for most people seeking cognitive benefits.
- Higher doses above 500 mg/kg in animal studies have shown potential for toxicity, so very high doses should be avoided.
- The search results recommend starting at the lower end of the 20-40 mg range and slowly increasing the dosage to assess individual tolerance.
Overall , a daily dose of 20-40 mg of PQQ is the recommended range for supporting cognitive function and brain health, with 21 mg per day being the specific dose used in the human study that demonstrated positive effects. Caution should be taken with extremely high doses.
How does PQQ compare to NMN for brain health:
Pyrroloquinoline quinone (PQQ) and Nicotinamide Mononucleotide (NMN) are both supplements that support brain health, but they have different mechanisms and benefits:
Mechanisms:
PQQ: PQQ is a potent antioxidant that supports brain function by enhancing mitochondrial function, improving energy production, and reducing oxidative stress. It also supports the growth of new mitochondria, which can help maintain healthy brain function.
NMN: NMN is a precursor to NAD+, which plays a crucial role in energy production and metabolism. NMN supplementation can increase NAD+ levels, enhancing cellular energy production and potentially improving brain function
Benefits:
PQQ: PQQ has been shown to improve cognitive function, memory, and executive speed in both younger and older adults. It also supports heart health by reducing cholesterol levels and triglycerides.
NMN: NMN has been found to improve blood pressure in patients with mild hypertension and may have anti-aging effects by enhancing cellular energy production and reducing oxidative stress
Dosage:
PQQ: Typical dosages of PQQ range from 20-40 mg per day, with some studies using higher doses up to 60 mg.
NMN: The recommended dosage of NMN varies, but some studies use 1000 mg per day to achieve significant effects on blood pressure and NAD+ levels
To sum up , both PQQ and NMN have unique mechanisms and benefits for brain health. PQQ is known for its antioxidant properties and ability to enhance mitochondrial function, while NMN is a precursor to NAD+ that supports energy production and metabolism. Combination of NMN and PQQ can improve cardiovascular health by regulating blood pressure, supporting mitochondrial function, reducing inflammation, improving cardiac function, and enhancing endothelial function.
Natural Sources of PQQ :
PQQ is naturally found in various foods, including:
- Fermented soybeans (natto)
- Spinach
- Green tea
- Kiwi fruit
- Papaya
- Dark Chocolate
Synthetic PQQ Supplements
Manufactured PQQ supplements are available to support those who may not get enough from their diet. These supplements are designed to provide a consistent and concentrated dose of PQQ.
Dietary Supplements vs. Functional Foods
PQQ can be consumed as a part of dietary supplements or through functional foods that have been fortified with this cofactor. Understanding the difference helps consumers choose the best method to integrate PQQ into their diet.
Symptoms and Signs of PQQ Deficiency
General Symptoms :
While there are no specific deficiency symptoms unique to PQQ, some general signs might include:
- Fatigue
- Cognitive decline
- Reduced immune function
Long-term Deficiency Effects:
Long-term deficiency may lead to more pronounced health issues such as:
- Increased oxidative stress
- Accelerated ageing
- Higher susceptibility to neurodegenerative diseases
Causes and Risk Factors
Biological Factors:
Genetic predispositions and metabolic disorders can influence how well the body utilises PQQ, potentially leading to lower levels.
Environmental Factors:
Dietary habits and exposure to environmental toxins can impact PQQ levels. Poor dietary choices and high exposure to pollutants may reduce the body’s ability to maintain adequate PQQ levels.
Lifestyle Factors:
Lifestyle choices, including stress, lack of sleep, and poor nutrition, can deplete PQQ levels and hinder its effectiveness in the body.
Diagnosis and Tests
Biomarker Identification:
Currently, there are no standardised tests specifically for PQQ levels. However, researchers are exploring biomarkers that could help in assessing PQQ status in the future.
Nutritional Assessment:
A comprehensive nutritional assessment by a healthcare professional can help identify potential PQQ deficiency by evaluating dietary intake and related health symptoms.
Treatment Options
Dietary Adjustments:
Increasing the intake of PQQ-rich foods like fermented soy, spinach, and green tea can naturally boost PQQ levels.
PQQ Supplementation:
Supplements are available in various forms, including capsules and powders. These can provide a consistent and higher dose of PQQ, particularly beneficial for those with specific health needs.
Combined Nutritional Therapy:
Combining PQQ with other antioxidants and nutrients can enhance its effectiveness and support overall health.
Preventive Measures
Regular Diet Incorporation:
Including PQQ-rich foods in daily meals can help maintain adequate levels and support overall health.
Healthy Lifestyle Practices:
Adopting a balanced diet, regular exercise, and stress management techniques can help optimise PQQ levels naturally.
Conclusion
Summary of Key Points:
PQQ has potent antioxidant and neuroprotective properties. It can protect against oxidative stress-induced cell damage and mitochondrial dysfunction. PQQ has been shown to stimulate growth, reproduction, and longevity .PQQ is a vital nutrient with significant roles in energy production and antioxidant defence. Its importance in human health is supported by emerging research, particularly in areas such as brain function and cardiovascular health.
